Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis.

ABSTRACT:

Background

Notch signaling involves ligand-receptor interactions through direct cell-cell contact. Multiple Notch receptors and ligands are expressed in the epidermis and hair follicles during embryonic development and the adult stage. Although Notch signaling plays an important role in regulating differentiation of the epidermis and hair follicles, it remains unclear how Notch signaling participates in late-stage epidermal differentiation and postnatal hair cycle homeostasis.

Methodology and principal findings

We applied Cre/loxP system to generate conditional gene targeted mice that allow inactivation of critical components of Notch signaling pathway in the skin. Rbpj, the core component of all four Notch receptors, and Pofut1, an essential factor for ligand-receptor inter

SUBMITTER: Lin HY 

PROVIDER: S-EPMC3022660 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature