The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load.

ABSTRACT:

Background

A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid β-oxidation. Chronic exposure to fatty acids due to an impaired β-oxidation may down-regulate the glucose-stimulated insulin release and result in an increased risk of type 2 diabetes (T2D). We aimed to investigate whether the two variants associate with altered insulin release following an oral glucose load or with T2D.

Methods

The variants were genotyped using KASPar® PCR SNP genotyping system and investigated for associations with estimates of in

SUBMITTER: Hornbak M 

PROVIDER: S-EPMC3022800 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature