Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila.

ABSTRACT:

Study objectives

Multiple lines of evidence indicate that sleep is important for the developing brain, although little is known about which cellular and molecular pathways are affected. Thus, the aim of this study was to determine whether the early adult life of Drosophila, which is associated with high amounts of sleep and critical periods of brain plasticity, could be used as a model to identify developmental processes that require sleep.

Subjects

Wild type Canton-S Drosophila melanogaster. DESIGN;

Intervention

Flies were sleep deprived on their first full day of adult life and allowed to recover undisturbed for at least 3 days. The animals were then tested for short-term memory and response-inhibition using aversive phototaxis suppression (APS). Components of dopam

SUBMITTER: Seugnet L 

PROVIDER: S-EPMC3022932 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature