Sleep related changes in blood pressure in hypocretin-deficient narcoleptic mice.

ABSTRACT:

Study objectives

Although blood pressure during sleep and the difference in blood pressure between sleep and wakefulness carry prognostic information, little is known on their central neural mechanisms. Hypothalamic neurons releasing hypocretin (orexin) peptides control wake-sleep behavior and autonomic functions and are lost in narcolepsy-cataplexy. We investigated whether chronic lack of hypocretin signaling alters blood pressure during sleep.

Design

Comparison of blood pressure as a function of the wake-sleep behavior between 2 different hypocretin-deficient mouse models and control mice with the same genetic background.

Setting

N/A.

Subjects

Hypocretin-ataxin3 transgenic mice with genetic ablation of hypocretin neurons (TG, n = 12); hypocretin gene knock-ou

SUBMITTER: Bastianini S 

PROVIDER: S-EPMC3022942 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature