Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus.

ABSTRACT:

Purpose

The aim of this study was to determine whether clinical outcome after surgical resection of esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) could be predicted by functional polymorphisms in different proto-oncogenes and tumor suppressor genes.

Experimental design

Six single nucleotide polymorphisms (SNPs) in the AURKA (rs2273535), ERBB2 (rs1136201), MDM2 (rs2279744), CDH1 (rs5030625), CDKN2A (rs11515), and TP73 (rs2273953) genes were genotyped in a consecutive cohort of 346 esophageal cancer patients, who had underwent surgical resection with curative intent. Associations with disease-free survival (DFS) were analyzed with Kaplan-Meier curves and Cox regression, adjusting for potential confounders.

Results

Univariate analysis showe

SUBMITTER: Boonstra JJ 

PROVIDER: S-EPMC3023032 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature