Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating.

ABSTRACT: Electrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a "pharmacy-on-a-chip"). Here we report the fabrication of nanoscale thin films that can release precise quantities of a small molecule drug in response to application of a small, anodic electric potential of at least +0.5 V versus Ag/AgCl. Films containing negatively charged Prussian Blue (PB) nanoparticles and positively charged gentamicin, a small hydrophilic antibiotic, were fabricated using layer-by-layer (LbL) assembly. When oxidized, the PB nanoparticles shift from negatively charged to neutral, inducing dissolution of the film. Films with thicknesses in the range 100-500 nm corresponding to drug loadings of 1-4 μg/

SUBMITTER: Schmidt DJ 

PROVIDER: S-EPMC3023308 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature