MicroRNAs both promote and antagonize longevity in C. elegans.

ABSTRACT:

Background

aging is under genetic control in C. elegans, but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in life span.

Results

here we show that multiple miRNAs change expression in C. elegans aging, including novel miRNAs, and that mutations in several of the most upregulated miRNAs lead to life-span defects. Some act to promote normal life span and stress resistance, whereas others inhibit these phenomena. We find that these miRNAs genetically interact with genes in the DNA damage checkpoint response pathway and in the insulin signaling pathway.

Conclusions

our findings reveal that miRNAs both positively and negatively influenc

SUBMITTER: de Lencastre A 

PROVIDER: S-EPMC3023310 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature