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Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.

ABSTRACT: C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation, and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence, and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.

SUBMITTER: Leutz A 

PROVIDER: S-EPMC3023639 | biostudies-literature | 2011 Jan-Feb

REPOSITORIES: biostudies-literature

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Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.

Leutz Achim A   Pless Ole O   Lappe Michael M   Dittmar Gunnar G   Kowenz-Leutz Elisabeth E  

Transcription 20110101 1

C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation, and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence, and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects t  ...[more]

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