Gene expression in cardiac tissues from infants with idiopathic conotruncal defects.

ABSTRACT:

Background

Tetralogy of Fallot (TOF) is the most commonly observed conotruncal congenital heart defect. Treatment of these patients has evolved dramatically in the last few decades, yet a genetic explanation is lacking for the failure of cardiac development for the majority of children with TOF. Our goal was to perform genome wide analyses and characterize expression patterns in cardiovascular tissue (right ventricle, pulmonary valve and pulmonary artery) obtained at the time of reconstructive surgery from 19 children with tetralogy of Fallot.

Methods

We employed genome wide gene expression microarrays to characterize cardiovascular tissue (right ventricle, pulmonary valve and pulmonary artery) obtained at the time of reconstructive surgery from 19 children with TOF (16 idio

SUBMITTER: Bittel DC 

PROVIDER: S-EPMC3023653 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature