Activity-dependent regulation of MHC class I expression in the developing primary visual cortex of the common marmoset monkey.

ABSTRACT:

Background

Several recent studies have highlighted the important role of immunity-related molecules in synaptic plasticity processes in the developing and adult mammalian brains. It has been suggested that neuronal MHCI (major histocompatibility complex class I) genes play a role in the refinement and pruning of synapses in the developing visual system. As a fast evolutionary rate may generate distinct properties of molecules in different mammalian species, we studied the expression of MHCI molecules in a nonhuman primate, the common marmoset monkey (Callithrix jacchus).

Methods and results

Analysis of expression levels of MHCI molecules in the developing visual cortex of the common marmoset monkeys revealed a distinct spatio-temporal pattern. High levels of expression were

SUBMITTER: Ribic A 

PROVIDER: S-EPMC3023691 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature