Time course of gene expression profiling in the liver of experimental mice infected with Echinococcus multilocularis.

ABSTRACT:

Background

Alveolar echinococcosis (AE) is a severe chronic parasitic disease which behaves like a slow-growing liver cancer. Clinical observations suggest that the parasite, Echinococcus multilocularis (E. multilocularis) influences liver homeostasis and hepatic cell metabolism. However, this has never been analyzed during the time course of infection in the common model of secondary echinococcosis in experimental mice.

Methodology/principal findings

Gene expression profiles were assessed using DNA microarray analysis, 1, 2, 3 and 6 months after injection of E. multilocularis metacestode in the liver of susceptible mice. Data were collected at different time points to monitor the dynamic behavior of gene expression. 557 differentially expressed genes were identified at one

SUBMITTER: Lin R 

PROVIDER: S-EPMC3023716 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature