Mesenteric lymph node transcriptome profiles in BALB/c mice sensitized to three common food allergens.

ABSTRACT:

Background

Food allergy is a serious health concern among infants and young children. Although immunological mechanism of food allergy is well documented, the molecular mechanism(s) involved in food allergen sensitization have not been well characterized. Therefore, the present study analyzed the mesenteric lymph node (MLN) transcriptome profiles of BALB/c mice in response to three common food allergens.

Results

Microarray analysis identified a total of 1361, 533 and 488 differentially expressed genes in response to β-lactoglobulin (BLG) from cow's milk, ovalbumin (OVA) from hen's egg white and peanut agglutinin (PNA) sensitizations, respectively (p < 0.05). A total of 150 genes were commonly expressed in all antigen sensitized groups. The expression of seven representative

SUBMITTER: Husain M 

PROVIDER: S-EPMC3023748 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature