The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons.

ABSTRACT: In neurogenesis, neural cell fate specification is generally triggered by proneural transcription factors. Whilst the role of proneural factors in fate specification is well studied, the link between neural specification and the cellular pathways that ultimately must be activated to construct specialised neurons is usually obscure. High-resolution temporal profiling of gene expression reveals the events downstream of atonal proneural gene function during the development of Drosophila chordotonal (mechanosensory) neurons. Among other findings, this reveals the onset of expression of genes required for construction of the ciliary dendrite, a key specialisation of mechanosensory neurons. We determine that atonal activates this cellular differentiation pathway in several ways. Firstly, atonal

SUBMITTER: Cachero S 

PROVIDER: S-EPMC3023811 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature