Fan-out in gene regulatory networks.

ABSTRACT:

Background

In synthetic biology, gene regulatory circuits are often constructed by combining smaller circuit components. Connections between components are achieved by transcription factors acting on promoters. If the individual components behave as true modules and certain module interface conditions are satisfied, the function of the composite circuits can in principle be predicted.

Results

In this paper, we investigate one of the interface conditions: fan-out. We quantify the fan-out, a concept widely used in electrical engineering, to indicate the maximum number of the downstream inputs that an upstream output transcription factor can regulate. The fan-out is shown to be closely related to retroactivity studied by Del Vecchio, et al. An efficient operational method for m

SUBMITTER: Kim KH 

PROVIDER: S-EPMC3024275 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature