Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers.

ABSTRACT:

Objective

Visceral adipose tissue (VAT) and hepatic fat are associated with insulin resistance and vary by sex and ethnicity. Recently, pancreatic fat fraction (PFF) has also been linked with increasing obesity. Our aim was to assess ethnic and sex differences in PFF and its relationship to other fat depots, circulating free fatty acids (FFA), insulin secretion and sensitivity, and inflammation in obese adolescents and young adults.

Research design and methods

We examined 138 (40 males, 98 females) obese Hispanics and African Americans (13-25 years). Subcutaneous adipose tissue and VAT volumes, hepatic fat fraction (HFF), and PFF were determined by magnetic resonance imaging. Insulin sensitivity and β-cell function were assessed during an intravenous glucose tolerance test.<

SUBMITTER: Le KA 

PROVIDER: S-EPMC3024373 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature