STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells.

ABSTRACT:

Background

Migration and proliferation of vascular endothelial cells are essential for repair of injured endothelium and angiogenesis. Cyclins, cyclin-dependent kinases (CDKs), and cyclin-dependent kinase inhibitors play an important role in vascular tissue injury and wound healing. Previous studies suggest a link between the cell cycle and cell migration: cells present in the G(1) phase have the highest potential to migrate. The molecular mechanism linking these two processes is not understood.

Methodology/principal findings

In this study, we explored the function of STK35L1, a novel Ser/Thr kinase, localized in the nucleus and nucleolus of endothelial cells. Molecular biological analysis identified a bipartite nuclear localization signal, and nucleolar localization sequenc

SUBMITTER: Goyal P 

PROVIDER: S-EPMC3024402 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature