Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.

ABSTRACT:

Background

An omphalocele is one of the major ventral body wall malformations and is characterized by abnormally herniated viscera from the body trunk. It has been frequently found to be associated with other structural malformations, such as genitourinary malformations and digit abnormalities. In spite of its clinical importance, the etiology of omphalocele formation is still controversial. Hedgehog (Hh) signaling is one of the essential growth factor signaling pathways involved in the formation of the limbs and urogenital system. However, the relationship between Hh signaling and ventral body wall formation remains unclear.

Methodology/principal findings

To gain insight into the roles of Hh signaling in ventral body wall formation and its malformation, we analyzed phenotyp

SUBMITTER: Matsumaru D 

PROVIDER: S-EPMC3024424 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature