Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.

ABSTRACT:

Objective

To determine whether information from genetic risk variants for diabetes is associated with cardiovascular events incidence.

Methods

From the about 30 known genes associated with diabetes, we genotyped single-nucleotide polymorphisms at the 10 loci most associated with type-2 diabetes in 425 subjects from the MASS-II Study, a randomized study in patients with multi-vessel coronary artery disease. The combined genetic information was evaluated by number of risk alleles for diabetes. Performance of genetic models relative to major cardiovascular events incidence was analyzed through Kaplan-Meier curve comparison and Cox Hazard Models and the discriminatory ability of models was assessed for cardiovascular events by calculating the area under the ROC curve.

Results

SUBMITTER: Sousa AG 

PROVIDER: S-EPMC3024434 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature