Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children.

ABSTRACT:

Background

Asthma exacerbations are a common cause of critical illness in children.

Objective

To determine factors associated with exacerbations in children with persistent asthma.

Methods

Regression modeling was used to identify historical, phenotypic, treatment, and time-dependent factors associated with the occurrence of exacerbations, defined by need for oral corticosteroids or emergency or hospital care in the 48-week Pediatric Asthma Controller Trial study. Children age 6 to 14 years with mild-to-moderate persistent asthma were randomized to receive either fluticasone propionate 100 microg twice daily (FP monotherapy), combination fluticasone 100 microg AM and salmeterol twice daily, or montelukast 5 mg once daily.

Results

Of the 285 participants randomiz

SUBMITTER: Covar RA 

PROVIDER: S-EPMC3024439 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature