Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment.

ABSTRACT:

Background

Statin use and serum cholesterol reduction have been proposed as preventions for dementia and mild cognitive impairment (MCI).

Methods

1604 and 1345 eligible participants from the Baltimore Longitudinal Study of Aging (BLSA) were followed after age 50 for a median time of around 25 years, to examine the incidence of dementia (n=259) and MCI (n=138), respectively. Statin use (ever-use and time-dependent use), total cholesterol levels (TC; first visit and time-dependent), TC change trajectory from first visit and high-density lipoprotein (HDL-C):TC ratio (first visit and time-dependent) were the main exposures of interest. Cox proportional hazards models were used.

Results

Participants with incident dementia had a higher first-visit TC compared with participa

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC3024452 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature