Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.

ABSTRACT:

Objective

There are theoretical reasons why comparing marker allele frequencies between cases of different diseases, rather than with controls, may offer benefits. The samples may be better matched, especially for background risk factors common to both diseases. Genetic loci may also be detected which influence which of the two diseases occurs if common risk factors are present.

Method

We used samples of UK bipolar and schizophrenic cases that had earlier been subject to genome-wide association studies and compared marker allele frequencies between the two samples. When these differed for a marker, we compared the case sample allele frequencies with those of a control sample.

Results

Eight markers were significant at P value of less than 10(-5). Of these, the most int

SUBMITTER: Curtis D 

PROVIDER: S-EPMC3024533 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature