Evolutionary analyses of Staphylococcus aureus identify genetic relationships between nasal carriage and clinical isolates.

ABSTRACT: Nasal carriage of Staphylococcus aureus has long been hypothesized to be a major vector for the transmission of virulent strains throughout the community. To address this hypothesis, we have analyzed the relatedness between a cohort of nasal carriage strains and clinical isolates to understand better the genetic conformity therein. To assess the relatedness between nasal carriage and clinical isolates of S. aureus, a genetic association study was conducted using multilocus sequence typing (MLST) and typing of the hypervariable regions of clumping factor and fibronectin binding protein genes. At all loci analyzed, genetic associations between both nasal carriage and clinical isolates were observed. Computational analyses of MLST data indicate that nasal carriage and clinical isolates belong

SUBMITTER: Lamers RP 

PROVIDER: S-EPMC3025037 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature