Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) risk-associated single-nucleotide polymorphisms (SNPs) are continuously being discovered. Their ability to identify men at high risk and the impact of increasing numbers of SNPs on predictive performance are not well understood.

Methods

Absolute risk for PCa was estimated in a population-based case-control study in Sweden (2,899 cases and 1,722 controls) using family history and three sets of sequentially discovered PCa risk-associated SNPs. Their performance in predicting PCa was assessed by positive predictive values (PPV) and sensitivity.

Results

SNPs and family history were able to differentiate individual risk for PCa and identify men at higher risk; ∼18% and ∼8% of men in the study had 20-year (55-74 years) absolute risks that we

SUBMITTER: Sun J 

PROVIDER: S-EPMC3025084 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature