Hemostatic markers are associated with the risk and prognosis of atrial fibrillation: the ARIC study.

ABSTRACT:

Background

Various hemostatic markers are associated with the risk of cardiovascular disease; however, limited information exists on their relationship with the occurrence and prognosis of atrial fibrillation (AF).

Objectives

To assess whether hemostatic markers are associated with the incidence and prognosis of AF.

Methods

We studied 14,858 men and women in the Atherosclerosis Risk in Communities cohort, aged 45-64 and free of AF at baseline (1987-1989). Fibrinogen, von Willebrand factor (vWf), factor VII activity (VIIc), factor VIII activity (VIIIc), protein C, antithrombin III (ATIII), and activated partial thromboplastin time (aPTT) were measured in blood samples at baseline. AF and other cardiovascular outcomes through 2005 were determined following standardized

SUBMITTER: Alonso A 

PROVIDER: S-EPMC3025309 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature