Gene expression variations are predictive for stochastic noise.

ABSTRACT: Fluctuations in protein abundance among single cells are primarily due to the inherent stochasticity in transcription and translation processes, such stochasticity can often confer phenotypic heterogeneity among isogenic cells. It has been proposed that expression noise can be triggered as an adaptation to environmental stresses and genetic perturbations, and as a mechanism to facilitate gene expression evolution. Thus, elucidating the relationship between expression noise, measured at the single-cell level, and expression variation, measured on population of cells, can improve our understanding on the variability and evolvability of gene expression. Here, we showed that noise levels are significantly correlated with conditional expression variations. We further demonstrated that expressio

SUBMITTER: Dong D 

PROVIDER: S-EPMC3025572 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature