A novel method for the genome-wide high resolution analysis of DNA damage.

ABSTRACT: DNA damage occurs via endogenous and exogenous genotoxic agents and compromises a genome's integrity. Knowing where damage occurs within a genome is crucial to understanding the repair mechanisms which protect this integrity. This paper describes a new development based on microarray technology which uses ultraviolet light induced DNA damage as a paradigm to determine the position and frequency of DNA damage and its subsequent repair throughout the entire yeast genome.

SUBMITTER: Teng Y 

PROVIDER: S-EPMC3025580 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature