Temporal waves of coherent gene expression during Drosophila embryogenesis.

ABSTRACT:

Motivation

Animal development depends on localized patterns of gene expression. Whole-genome methods permit the global identification of differential expression patterns. However, most gene-expression-clustering methods focus on the analysis of entire expression profiles, rather than temporal segments or time windows.

Results

In the current study, local clustering of temporal time windows was applied to developing embryos of the fruitfly, Drosophila melanogaster. Large-scale developmental events, involving temporal activation of hundreds of genes, were identified as discrete gene clusters. The time-duration analysis revealed six temporal waves of coherent gene expression during Drosophila embryogenesis. The most powerful expression waves preceded major morphogenetic movement

SUBMITTER: Papatsenko I 

PROVIDER: S-EPMC3025744 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature