Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes.

ABSTRACT:

Objectives

To better understand the relationship between angiotensinogen (AGT) genetic variation and essential hypertension, AGT genotypes and haplotypes were tested for association with hypertensive endophenotypes and essential hypertension.

Methods

Two hundred and fifty-six Hypertensive Pathotype (HyperPATH)/Specialized Center of Research (SCOR) cases and 126 controls were genotyped for 24 single-nucleotide polymorphisms (SNPs) in the AGT gene. SNPs and AGT haplotypes were tested for association with plasma AGT, renal plasma flow (RPF), and essential hypertension.

Results

New associations between essential hypertension, plasma AGT, and RPF are reported for alleles -1178G, 6066A, 6152A, 6233C, and 12822C. The maximum odds ratio for association of hypertension and AGT

SUBMITTER: Watkins WS 

PROVIDER: S-EPMC3025818 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature