TEAD1-dependent expression of the FoxO3a gene in mouse skeletal muscle.

ABSTRACT:

Background

TEAD1 (TEA domain family member 1) is constitutively expressed in cardiac and skeletal muscles. It acts as a key molecule of muscle development, and trans-activates multiple target genes involved in cell proliferation and differentiation pathways. However, its target genes in skeletal muscles, regulatory mechanisms and networks are unknown.

Results

In this paper, we have identified 136 target genes regulated directly by TEAD1 in skeletal muscle using integrated analyses of ChIP-on-chip. Most of the targets take part in the cell process, physiology process, biological regulation metabolism and development process. The targets also play an important role in MAPK, mTOR, T cell receptor, JAK-STAT, calcineurin and insulin signaling pathways. TEAD1 regulates foxo3a tran

SUBMITTER: Qiu H 

PROVIDER: S-EPMC3025863 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature