Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.

ABSTRACT:

Background

SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ovarian cancer. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.

Methods

We genotyped five common (minor allele frequency>0.05) regulatory SNPs with predicted functionalities (rs2623047 G>A, rs13264163 A>G, rs6990375 G>A, rs3802278 G>A, and rs3087714 C>T) in 168 patients with primary epithelial ovarian cancer, using the polymerase chain reaction-restriction fragment length polymorphism method.

Results

We found that rs2623047 G>A was significantly associated with an ea

SUBMITTER: Han CH 

PROVIDER: S-EPMC3025876 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature