Complete coding sequence characterization and comparative analysis of the putative novel human rhinovirus (HRV) species C and B.

ABSTRACT:

Background

Human Rhinoviruses (HRVs) are well recognized viral pathogens associated with acute respiratory tract illnesses (RTIs) abundant worldwide. Although recent studies have phylogenetically identified the new HRV species (HRV-C), data on molecular epidemiology, genetic diversity, and clinical manifestation have been limited.

Result

To gain new insight into HRV genetic diversity, we determined the complete coding sequences of putative new members of HRV species C (HRV-CU072 with 1% prevalence) and HRV-B (HRV-CU211) identified from clinical specimens collected from pediatric patients diagnosed with a symptom of acute lower RTI. Complete coding sequence and phylogenetic analysis revealed that the HRV-CU072 strain shared a recent common ancestor with most closely related C

SUBMITTER: Linsuwanon P 

PROVIDER: S-EPMC3025962 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature