Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance.

ABSTRACT:

Background

Hen's egg allergy is among the most common food allergies in childhood and predicts later development of allergic disease. The optimal efficacy and mechanism(s) of egg allergen immunotherapy are poorly understood.

Objective

To enhance immunologic and clinical outcomes of egg oral immunotherapy (OIT) using a conditionally increased dosing strategy.

Methods

In an open-label clinical trial of egg OIT, egg-allergic children ingested daily doses of egg protein that were gradually increased based on the egg white (EW) IgE level. Skin prick test reactivity and EW- and ovomucoid-specific cellular and humoral responses were measured longitudinally. To confirm clinical tolerance, patients underwent double-blinded, placebo-controlled food challenges 1 month after comp

SUBMITTER: Vickery BP 

PROVIDER: S-EPMC3026291 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature