Next generation models for storage and representation of microbial biological annotation.

ABSTRACT:

Background

Traditional genome annotation systems were developed in a very different computing era, one where the World Wide Web was just emerging. Consequently, these systems are built as centralized black boxes focused on generating high quality annotation submissions to GenBank/EMBL supported by expert manual curation. The exponential growth of sequence data drives a growing need for increasingly higher quality and automatically generated annotation. Typical annotation pipelines utilize traditional database technologies, clustered computing resources, Perl, C, and UNIX file systems to process raw sequence data, identify genes, and predict and categorize gene function. These technologies tightly couple the annotation software system to hardware and third party software (e.g. relat

SUBMITTER: Quest DJ 

PROVIDER: S-EPMC3026362 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature