Clusters of temporal discordances reveal distinct embryonic patterning mechanisms in Drosophila and anopheles.

ABSTRACT: Evolutionary innovations can be driven by spatial and temporal changes in gene expression. Several such differences have been documented in the embryos of lower and higher Diptera. One example is the reduction of the ancient extraembryonic envelope composed of amnion and serosa as seen in mosquitoes to the single amnioserosa of fruit flies. We used transcriptional datasets collected during the embryonic development of the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae, to search for whole-genome changes in gene expression underlying differences in their respective embryonic morphologies. We found that many orthologous gene pairs could be clustered based on the presence of coincident discordances in their temporal expression profiles. One such cluster contai

SUBMITTER: Papatsenko D 

PROVIDER: S-EPMC3026761 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature