Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets.

ABSTRACT:

Background

A better understanding of reproductive processes in parasitic nematodes may lead to development of new anthelmintics and control strategies for combating disabling and disfiguring neglected tropical diseases such as lymphatic filariasis and onchocerciasis. Transcriptomatic analysis has provided important new insights into mechanisms of reproduction and development in other invertebrates. We have performed the first genome-wide analysis of gender-associated (GA) gene expression in a filarial nematode to improve understanding of key reproductive processes in these parasites.

Methodology/principal findings

The Version 2 Filarial Microarray with 18,104 elements representing ∼85% of the filarial genome was used to identify GA gene transcripts in adult Brugia malayi wor

SUBMITTER: Li BW 

PROVIDER: S-EPMC3026763 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature