Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity.

ABSTRACT: A hallmark of meiosis is the precise pairing and the stable physical connection (synapsis) of the homologous chromosomes. These processes are essential prerequisite for their proper segregation. Pairing of the homologs during meiotic prophase I critically depends on characteristic movements of chromosomes. These movements, in turn, require attachment of meiotic telomeres to the nuclear envelope and their subsequent dynamic repositioning. Dynamic repositioning of meiotic telomeres goes along with profound structural reorganization of the nuclear envelope. The short A-type lamin C2 is thought to play a critical role in this process due to its specific expression during meiotic prophase I and the unique localization surrounding telomere attachments. Consistent with this notion, here we provid

SUBMITTER: Jahn D 

PROVIDER: S-EPMC3027034 | biostudies-literature | 2010 May-Jun

REPOSITORIES: biostudies-literature