Membrane-coating lattice scaffolds in the nuclear pore and vesicle coats: commonalities, differences, challenges.

ABSTRACT: The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ∼30 nucleoporins (nups). Structural studies of the NPC have been limited by its considerable size and complexity. Progress toward understanding the structure of this nanomachine has benefited from its modular nature, which allows for this 40-60 MDa assembly to be broken down into subcomplexes that can be studied individually. While recent work by both crystallographers and electron microscopists has greatly enhanced our model of the NPC, the resolution gap between crystal and EM structures remains too large to confidently place individual proteins within the context of the fully assembled NPC. In an effort to arrive at a veritable model o

SUBMITTER: Leksa NC 

PROVIDER: S-EPMC3027038 | biostudies-literature | 2010 Jul-Aug

REPOSITORIES: biostudies-literature