Inflammation in the avian spleen: timing is everything.

ABSTRACT:

Background

The synchrony of an organism with both its external and internal environment is critical to well-being and survival. As a result, organisms display daily cycles of physiology and behavior termed circadian rhythms. At the cellular level, circadian rhythms originate via interlocked autoregulatory feedback loops consisting of circadian clock genes and their proteins. These regulatory loops provide the molecular framework that enables the intracellular circadian timing system necessary to generate and maintain subsequent 24 hr rhythms. In the present study we examine the daily control of circadian clock genes and regulation of the inflammatory response by the circadian clock in the spleen.

Results

Our results reveal that circadian clock genes as well as proinflammator

SUBMITTER: Naidu KS 

PROVIDER: S-EPMC3027090 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature