Maternal folate-related gene environment interactions and congenital heart defects.

ABSTRACT:

Objective

To investigate whether women with congenital heart defect (CHD)-affected pregnancies were more likely to have functional single-nucleotide polymorphisms in genes encoding enzymes in folate-dependent pathways.

Methods

A population-based case-control study of 572 women with CHD-affected pregnancies and 363 women in the control group was conducted. DNA samples were genotyped for single-nucleotide polymorphisms in three genes encoding for folate pathway enzymes. Maternal lifestyle factor information was obtained using standardized interviews.

Results

Women in the case group were 1.5 times more likely to be obese (body mass index of 30 or higher) compared with those in the control group. Obese women carrying the MTHFR TT genotype were 4.6 times more likely to hav

SUBMITTER: Hobbs CA 

PROVIDER: S-EPMC3027124 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature