Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity.

ABSTRACT: Recent studies have shown that tissue resident memory T cells (T(RM)) are critical to antiviral host defense in peripheral tissues. This new appreciation of T(RM) that reside in epithelial tissues and mediate host defense has been studied most extensively in skin: adult human skin contains large numbers of functional T(RM) that express skin specific markers. Indeed, more than twice as many T cells reside in skin as in peripheral blood. This T cell population has a diverse T cell receptor repertoire, and can produce a broad array of cytokines. More recently, we have begun to examine other epithelial tissues for the presence of resident T cells. In the present study, we asked whether analogous populations of resident T cells could be found in human lung. We were able to demonstrate abundant

SUBMITTER: Purwar R 

PROVIDER: S-EPMC3027667 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature