Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.

ABSTRACT: Acute lung injury (ALI) and mechanical ventilator-induced lung injury (VILI), major causes of acute respiratory failure with elevated morbidity and mortality, are characterized by significant pulmonary inflammation and alveolar/vascular barrier dysfunction. Previous studies highlighted the role of the non-muscle myosin light chain kinase isoform (nmMLCK) as an essential element of the inflammatory response, with variants in the MYLK gene that contribute to ALI susceptibility. To define nmMLCK involvement further in acute inflammatory syndromes, we used two murine models of inflammatory lung injury, induced by either an intratracheal administration of lipopolysaccharide (LPS model) or mechanical ventilation with increased tidal volumes (the VILI model). Intravenous delivery of the membrane-

SUBMITTER: Mirzapoiazova T 

PROVIDER: S-EPMC3028257 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature