Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans.

ABSTRACT:

Objective

The metabolism of hepatic- and intestinally derived lipoproteins is regulated in a complex fashion by nutrients, hormones, and neurologic and other factors. Recent studies in animal models suggest an important role for glucagon acting via the glucagon receptor in regulating hepatic triglyceride (TG) secretion. Here we examined the direct effects of glucagon on regulation of hepatic and intestinal lipoprotein metabolism in humans.

Research design and methods

Eight healthy men underwent two studies each, in random order, 4-6 weeks apart in which de novo lipogenesis, kinetics of larger VLDL1 TG, and kinetics of VLDL1 and smaller VLDL2 apolipoprotein (apo)B100 and B48 were studied using established stable isotope enrichment methods. Subjects were studied in the constan

SUBMITTER: Xiao C 

PROVIDER: S-EPMC3028336 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature