Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction.

ABSTRACT:

Aims

galectin-3 is an emerging biomarker which has been studied in relatively small heart failure (HF) cohorts with predominantly systolic HF. We studied the prognostic value of base-line galectin-3 in a large HF cohort, with preserved and reduced left ventricular ejection fraction (LVEF), and compared this to other biomarkers.

Methods

we studied 592 HF patients who had been hospitalized for HF and were followed for 18 months. The primary end-point was a composite of all-cause mortality and HF hospitalization.

Results

a doubling of galectin-3 levels was associated with a hazard ratio (HR) of 1.97 (1.62-2.42) for the primary outcome (P < 0.001). After correction for age, gender, BNP, eGFR, and diabetes the HR was 1.38 (1.07-1.78; P = 0.015). Galectin-3 levels were corr

SUBMITTER: de Boer RA 

PROVIDER: S-EPMC3028573 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature