Among developmental regulators, StuA but not BrlA is essential for penicillin V production in Penicillium chrysogenum.

ABSTRACT: In filamentous fungi, secondary metabolism is often linked with developmental processes such as conidiation. In this study we analyzed the link between secondary metabolism and conidiation in the main industrial producer of the β-lactam antibiotic penicillin, the ascomycete Penicillium chrysogenum. Therefore, we generated mutants defective in two central regulators of conidiation, the transcription factors BrlA and StuA. Inactivation of either brlA or stuA blocked conidiation and altered hyphal morphology during growth on solid media, as shown by light and scanning electron microscopy, but did not affect biomass production during liquid-submerged growth. Genome-wide transcriptional profiling identified a complex StuA- and BrlA-dependent regulatory network, including genes previously shown

SUBMITTER: Sigl C 

PROVIDER: S-EPMC3028705 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature