Distinct time-resolved roles for two catabolite-sensing pathways during Streptococcus pyogenes infection.

ABSTRACT: Many Gram-positive pathogens link the expression of virulence genes to the presence of carbon source substrates using overlapping pathways for global control of carbon catabolite regulation. However, how these pathways are integrated to control the behavior of the transcriptome in time- and compartment-specific patterns is typically not well understood. In the present study, global transcriptome profiling was used to determine the extent to which glucose alters gene expression in Streptococcus pyogenes (group A streptococcus) and the contributions of the CcpA and LacD.1 catabolite control pathways to the regulation of this response in vitro. This analysis revealed that the expression of as many as 15% of the genes examined was regulated and that CcpA and LacD.1 together contribute to the r

SUBMITTER: Kietzman CC 

PROVIDER: S-EPMC3028826 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature