Asymmetric synthesis of tertiary benzylic alcohols.

ABSTRACT: Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups.

SUBMITTER: Antczak MI 

PROVIDER: S-EPMC3028934 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature