Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study.

ABSTRACT:

Background

Polybrominated diphenyl ethers (PBDEs) are flame retardants used widely and in increasing amounts in the U.S. over the last few decades. PBDEs and their metabolites cross the placenta and studies in rodents demonstrate neurodevelopmental toxicity from prenatal exposures. PBDE exposures occur both via breastfeeding and hand-to-mouth activities in small children.

Methods

Participants were 100 children from the CHARGE (CHildhood Autism Risk from Genetics and the Environment) Study, a case-control epidemiologic investigation of children with autism/autism spectrum disorder, with developmental delay and from the general population. Diagnoses of autism were confirmed by the Autism Diagnostic Observation Schedule and Autism Diagnostic Inventory-Revised, and of developmen

SUBMITTER: Hertz-Picciotto I 

PROVIDER: S-EPMC3029221 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature