MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis.

ABSTRACT:

Background

SRY (sex-determining region Y)-box 2 (SOX2) is a crucial transcription factor for the maintenance of embryonic stem cell pluripotency and the determination of cell fate. Previously, we demonstrated that SOX2 plays important roles in growth inhibition through cell cycle arrest and apoptosis, and that SOX2 expression is frequently down-regulated in gastric cancers. However, the mechanisms underlying loss of SOX2 expression and its target genes involved in gastric carcinogenesis remain largely unknown. Here, we assessed whether microRNAs (miRNAs) regulate SOX2 expression in gastric cancers. Furthermore, we attempted to find downstream target genes of SOX2 contributing to gastric carcinogenesis.

Methodology/principal findings

We performed in silico analysis and focuse

SUBMITTER: Otsubo T 

PROVIDER: S-EPMC3029394 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature