Continuum model of collective cell migration in wound healing and colony expansion.

ABSTRACT: Collective cell migration plays an important role during wound healing and embryo development. Although the exact mechanisms that coordinate such migration are still unknown, experimental studies of moving cell layers have shown that the primary interactions governing the motion of the layer are the force of lamellipodia, the adhesion of cells to the substrate, and the adhesion of cells to each other. Here, we derive a two-dimensional continuum mechanical model of cell-layer migration that is based on a novel assumption of elastic deformation of the layer and incorporates basic mechanical interactions of cells as well as cell proliferation and apoptosis. The evolution equations are solved numerically using a level set method. The model successfully reproduces data from two types of experim

SUBMITTER: Arciero JC 

PROVIDER: S-EPMC3030184 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature