The origin of the Haitian cholera outbreak strain.

ABSTRACT:

Background

Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera in Haiti.

Methods

We used third-generation single-molecule real-time DNA sequencing to determine the genome sequences of 2 clinical Vibrio cholerae isolates from the current outbreak in Haiti, 1 strain that caused cholera in Latin America in 1991, and 2 strains isolated in South Asia in 2002 and 2008. Using primary sequence data, we compared the genomes of these 5 strains and a set of previously obtained partial genomic sequences of 23 diverse strains of V. cholerae to assess the likely origin of the cholera outbreak in Haiti.

Results

Both single-nucleotide variations and the

SUBMITTER: Chin CS 

PROVIDER: S-EPMC3030187 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature